Corydalmine (hydrochloride)

CAT: 0804-HY-N2573ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-N2573ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Corydalmine hydrochloride inhibits spore germination of some plant pathogenic as well as saprophytic fungi[1]. Corydalmine hydrochloride acts as an oral analgesic agent, exhibiting potent analgesic activity[2]. Corydalmine hydrochloride alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway[3].
CAS Number
[2428393-60-4]
Product Name Alternative
L-Corydalmine (hydrochloride) ; TLZ-16-CL
UNSPSC
12352005
Target
CXCR; Fungal
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/corydalmine-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=C2C(CN3CCC4=CC(OC)=C(OC)C=C4[C@]3([H])C2)=C1OC.[H]Cl
Molecular Formula
C20H24ClNO4
Molecular Weight
377.86
References & Citations
[1]Basha SA, Jha RN, Pandey VB, Singh UP. Effect of 1-corydalmine, an Alkaloid Isolated from Corydalis chaerophylla Roots on Spore Germination of Some Fungi. Mycobiology. 2007;35 (2) :69-71.|[2]Tang X, Di X, Zhong Z, et al. In vitro metabolism of l-corydalmine, a potent analgesic drug, in human, cynomolgus monkey, beagle dog, rat and mouse liver microsomes. J Pharm Biomed Anal. 2016;128:98-105.|[3]Zhou L, Hu Y, Li C, et al. Levo-corydalmine alleviates vincristine-induced neuropathic pain in mice by inhibiting an NF-kappa B-dependent CXCL1/CXCR2 signaling pathway. Neuropharmacology. 2018;135:34-47.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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