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Dabuzalgron (hydrochloride)

CAT: 0804-HY-117071ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117071ASize:1 Each
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Description
Dabuzalgron (Ro 115-1240) hydrochloride is an orally active and selective α-1A adrenergic receptor agonist for the treatment of urinary incontinence. Dabuzalgron hydrochloride protects against Doxorubicin-induced cardiotoxicity by preserving mitochondrial function[1].
CAS Number
219311-43-0
Product Name Alternative
Ro 115-1240 (hydrochloride)
UNSPSC
12352005
Target
Adrenergic Receptor; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Neuronal Signaling
Field of Research
Endocrinology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/dabuzalgron-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CS(=O)(NC1=C(C=CC(OCC2=NCCN2)=C1C)Cl)=O.Cl
Molecular Formula
C12H17Cl2N3O3S
Molecular Weight
354.25
References & Citations
[1]Beak J, et al. An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity. JACC Basic Transl Sci. 2017 Feb;2 (1) :39-53.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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