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Harmol

CAT: 0804-HY-107811-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107811-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Harmol is an orally active β-carboline alkaloid. Harmol is a TFEB activator and monoamine oxidase inhibitor. Harmol can induce cell mitosis, Autophagy and Apoptosis. Harmol promotes the degradation of α-synuclein by regulating the autophagy-lysosomal pathway. Harmol has anti-tumor, anti-depressant and anti-aging activities. Harmol improves motor impairment in a mouse Parkinson's disease model[1][2][3][4].
CAS Number
487-03-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Mitosis; Monoamine Oxidase; α-synuclein
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/harmol.html
Purity
99.77
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
OC1=CC2=C(C=C1)C3=C(C(C)=NC=C3)N2
Molecular Formula
C12H10N2O
Molecular Weight
198.22
Precautions
H302, H315, H319, H335
References & Citations
[1]Jie Xu, et al. Harmol promotes α-synuclein degradation and improves motor impairment in Parkinson's models via regulating autophagy-lysosome pathway. NPJ Parkinsons Dis. 2022 Aug 6;8 (1) :100.|[2]Akihisa Abe , et al. Harmol induces autophagy and subsequent apoptosis in U251MG human glioma cells through the downregulation of surviving. Oncol Rep. 2013 Apr;29 (4) :1333-42.|[3]Akihisa Abe, et al. Harmol induces apoptosis by caspase-8 activation independently of Fas/Fas ligand interaction in human lung carcinoma H596 cells. Anticancer Drugs. 009 Jun;20 (5) :373-81.|[4]Luis Filipe Costa-Machado, et al. Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models. Nat Commun. 2023 May 15;14 (1) :2779.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
α-synuclein

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