GT-02216

• Description:

  GT-02216 can bind to GCase allosterically and enhance its activity. GT-02216 enhances the activity of GCase in primary human fibroblasts dose-dependently reduces the accumulation of its substrate, hexosylsphingosine (HexCer) . GT-02216 reduces the Tau accumulation in mutant GBA1 fibroblasts. GT-02216 can be used for the study of Parkinson’s disease[1].

• UNSPSC:

  12352005

• Target:

  Glycosidase

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Metabolic Disease; Neurological Disease

• Purity:

  98.91

• Smiles:

  O=C(C1=NC(N)=CC(NC2=C(O)C=CC=C2)=C1)N(CC3)CCN3C4=CC=CC=C4

• Molecular Formula:

  C22H23N5O2

• Molecular Weight:

  389.45

• References & Citations:

  WTL444P/L444P

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2648407-76-3]