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Org-24598

CAT: 0804-HY-10712-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10712-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Org-24598 is an inhibitor of glycine transporter 1 GlyT-1 . Org-24598 can inhibit the specific binding of [3H] CHIBIA-3007 to the rat brain membranes with a Ki value of 16.9 nM[1].
CAS Number
372198-97-5
UNSPSC
12352005
Target
GlyT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/org-24598.html
Solubility
10 mM in DMSO
Smiles
CN(CC(O)=O)CC[C@@H](OC1=CC=C(C(F)(F)F)C=C1)C2=CC=CC=C2
Molecular Formula
C19H20F3NO3
Molecular Weight
367.36
References & Citations
[1]Zhang J, et al. Pharmacological characterization of [³H]CHIBA-3007 binding to glycine transporter 1 in the rat brain. PLoS One. 2011;6 (6) :e21322.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Org 24598

structure in first source

CAS Number372198-97-5
PubChem CID5311285
IUPAC Name2-[methyl-[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]amino]acetic acid
Molecular FormulaC19H20F3NO3
Molecular Weight367.4
XLogP1.8
Topological Polar Surface Area49.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Heavy Atom Count26
Formal Charge0
Complexity430
SMILES
CN(CC[C@H](C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F)CC(=O)O
InChI
InChI=1S/C19H20F3NO3/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22/h2-10,17H,11-13H2,1H3,(H,24,25)/t17-/m1/s1
InChIKey
KZWQAWBTWNPFPW-QGZVFWFLSA-N
Chemical Structure
2D Structure
2D structure of Org 24598
CAS: 372198-97-5
CID: 5311285
Formula: C19H20F3NO3
MW: 367.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight367.4
XLogP31.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Exact Mass367.13952799
Monoisotopic Mass367.13952799
Topological Polar Surface Area49.8 Ų
Heavy Atom Count26
Formal Charge0
Complexity430
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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