Org-12962

CAT: 0804-HY-118152-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-118152-01Size:5 mg
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Description
Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively[1][3].Org-12962 displays antiaversive effects in a rat model of panic-like anxiety[2].
CAS Number
[132834-56-1]
Product Name Alternative
SR-202
UNSPSC
12352005
Hazard Statement
H301, H311, H331
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/org-12962.html
Purity
99.93
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
FC(F)(F)C1=C(N=C(C=C1)N2CCNCC2)Cl
Molecular Formula
C10H11ClF3N3
Molecular Weight
265.66
Precautions
H301, H311, H331
References & Citations
[1]Porter RH, et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.Br J Pharmacol. 1999 Sep;128 (1) :13-20.|[2]Jenck F, et al. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.Eur Neuropsychopharmacol. 1998 Aug;8 (3) :161-8.|[3]Faassen F, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.Int J Pharm. 2003 Sep 16;263 (1-2) :113-22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor; α-1 microglobulin

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