Org-12962

• Description :

  Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively[1][3].Org-12962 displays antiaversive effects in a rat model of panic-like anxiety[2].

• CAS Number :

  [132834-56-1]

• Product Name Alternative :

  SR-202

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H311, H331

• Target :

  5-HT Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/org-12962.html

• Purity :

  99.93

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  FC(F)(F)C1=C(N=C(C=C1)N2CCNCC2)Cl

• Molecular Formula :

  C10H11ClF3N3

• Molecular Weight :

  265.66

• Precautions :

  H301, H311, H331

• References & Citations :

  [1]Porter RH, et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.Br J Pharmacol. 1999 Sep;128 (1) :13-20.|[2]Jenck F, et al. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.Eur Neuropsychopharmacol. 1998 Aug;8 (3) :161-8.|[3]Faassen F, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.Int J Pharm. 2003 Sep 16;263 (1-2) :113-22.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT2 Receptor; α-1 microglobulin