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Org-9935

CAT: 0804-HY-120029Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-120029Size:1 Each
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Description
Org-9935 is a selective inhibitor of PDE3 with an IC50 of 50 nM. Org-9935 inhibits maturation of oocyte in naturally selected dominant follicle in rhesus macaques. Org-9935 can augment glucose-induced insulin release in isolated rat islets with an EC50 of 20 μM[1][2][3].
CAS Number
129425-83-8
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology
Smiles
O=C1CC(C)C(C2=CC3=CC(OC)=C(OC)C=C3S2)=NN1
Molecular Formula
C15H16N2O3S
Molecular Weight
304.36
References & Citations
[1]Dent, G., et al., (1991) . Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan-stimulated respiratory burst by 'type IV'-selective PDE inhibitors. British journal of pharmacology, 103 (2), 1339-1346. |[2]El-Metwally, M., et al., (1997) . The effect of selective phosphodiesterase inhibitors on plasma insulin concentrations and insulin secretion in vitro in the rat. European journal of pharmacology, 324 (2-3), 227-232. |[3]Jensen, J. T., et al., (2008) . The phosphodiesterase 3 inhibitor ORG 9935 inhibits oocyte maturation in the naturally selected dominant follicle in rhesus macaques. Contraception, 77 (4), 303-307.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

6-(5,6-Dimethoxybenzo(b)thien-2-yl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
CAS Number129425-83-8
PubChem CID131100
IUPAC Name3-(5,6-dimethoxy-1-benzothiophen-2-yl)-4-methyl-4,5-dihydro-1H-pyridazin-6-one
Molecular FormulaC15H16N2O3S
Molecular Weight304.4
XLogP2.8
Topological Polar Surface Area88.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count21
Formal Charge0
Complexity443
SMILES
CC1CC(=O)NN=C1C2=CC3=CC(=C(C=C3S2)OC)OC
InChI
InChI=1S/C15H16N2O3S/c1-8-4-14(18)16-17-15(8)13-6-9-5-10(19-2)11(20-3)7-12(9)21-13/h5-8H,4H2,1-3H3,(H,16,18)
InChIKey
KIYDKXDCNSPKQQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6-(5,6-Dimethoxybenzo(b)thien-2-yl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
CAS: 129425-83-8
CID: 131100
Formula: C15H16N2O3S
MW: 304.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight304.4
XLogP32.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass304.08816355
Monoisotopic Mass304.08816355
Topological Polar Surface Area88.2 Ų
Heavy Atom Count21
Formal Charge0
Complexity443
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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