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CP-544439

CAT: 0804-HY-107013-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-107013-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 0.75 nM[1][2].
CAS Number
[230954-09-3]
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cp-544439.html
Solubility
10 mM in DMSO
Smiles
O=C(NO)C1(CCOCC1)NS(=O)(C2=CC=C(C=C2)OC3=CC=C(C=C3)F)=O
Molecular Formula
C18H19FN2O6S
Molecular Weight
410.42
References & Citations
[1]Dalvie D, et al. Metabolism distribution and excretion of a matrix metalloproteinase-13 inhibitor, 4-[4- (4-fluorophenoxy) -benzenesulfonylamino]tetrahydropyran-4-carboxylic acid hydroxyamide (CP-544439), in rats and dogs: assessment of the metabolic profile of CP-544439 in plasma and urine of humans. Drug Metab Dispos. 2008;36 (9) :1869-1883.|[2]Reiter LA, et al. Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1. Bioorg Med Chem Lett. 2004;14 (13) :3389-3395.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-1; MMP-12; MMP-13; MMP-14; MMP-2; MMP-3; MMP-8; MMP-9

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