CP-544439

• Description :

  CP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 0.75 nM[1][2].

• UNSPSC :

  12352005

• Target :

  MMP

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/cp-544439.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NO)C1(CCOCC1)NS(=O)(C2=CC=C(C=C2)OC3=CC=C(C=C3)F)=O

• Molecular Formula :

  C18H19FN2O6S

• Molecular Weight :

  410.42

• References & Citations :

  [1]Dalvie D, et al. Metabolism distribution and excretion of a matrix metalloproteinase-13 inhibitor, 4-[4- (4-fluorophenoxy) -benzenesulfonylamino]tetrahydropyran-4-carboxylic acid hydroxyamide (CP-544439), in rats and dogs: assessment of the metabolic profile of CP-544439 in plasma and urine of humans. Drug Metab Dispos. 2008;36 (9) :1869-1883.|[2]Reiter LA, et al. Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1. Bioorg Med Chem Lett. 2004;14 (13) :3389-3395.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MMP-1; MMP-12; MMP-13; MMP-14; MMP-2; MMP-3; MMP-8; MMP-9

• CAS Number :

  [230954-09-3]