LWG-301

• Target:

  Others|||Apoptosis|||Glutaminase

• Related Pathways:

  Proteases/Proteasome|||Others|||Apoptosis

• Bioactivity:

  LWG-301, an allosteric inhibitor of Glutaminase 1 (GLS1), demonstrates a potent inhibition with an IC50 value of 7 nM. It effectively impedes glutamine metabolism and elevates intracellular ROS levels, thereby inducing apoptosis. Additionally, LWG-301 shows moderate antitumor efficacy in the HCT116 xenograft model.

• Smiles:

  CCCCC(=O)NC1=NN=C(S1)NC2CCN(CC2)C3=NN=C(C=C3)NC(=O)CC4=CC(=CC=C4)OCCCC

• Molecular Formula:

  C28H38N8O3S

• Molecular Weight:

  566.72

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C