RMC-0331

• Description:

  RMC-0331 (RM-023) is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction[1].

• Product Name Alternative:

  RM-023

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319

• Target:

  Ras; SHP2; SOS1

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/rmc-0331.html

• Concentration:

  10mM

• Purity:

  98.96

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C(N1CC2=NC(Cl)=NC(N[C@@H](C3=CC(C(F)(F)F)=CC(N)=C3)C)=C2C1)C4(OC)CCOCC4

• Molecular Formula:

  C22H25ClF3N5O3

• Molecular Weight:

  499.91

• Precautions:

  H315, H319

• References & Citations:

  [1]Andreas Buckl, et al. Discovery of a Potent, Selective and Orally Bioavailable SOS1 Inhibitor, RMC-0331 (RM-023), an in vivo Tool Compound that Blocks RAS Activation via Disruption of the RAS-SOS1 Interaction.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2488788-52-7]