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RMC-0331

CAT: 0804-HY-134885-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-134885-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RMC-0331 (RM-023) is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction[1].
CAS Number
2488788-52-7
Product Name Alternative
RM-023
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Ras; SHP2; SOS1
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rmc-0331.html
Concentration
10mM
Purity
98.96
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(N1CC2=NC(Cl)=NC(N[C@@H](C3=CC(C(F)(F)F)=CC(N)=C3)C)=C2C1)C4(OC)CCOCC4
Molecular Formula
C22H25ClF3N5O3
Molecular Weight
499.91
Precautions
H315, H319
References & Citations
[1]Andreas Buckl, et al. Discovery of a Potent, Selective and Orally Bioavailable SOS1 Inhibitor, RMC-0331 (RM-023), an in vivo Tool Compound that Blocks RAS Activation via Disruption of the RAS-SOS1 Interaction.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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