LE-540

• Description :

  LE-540 is a RARβ-selective retinoic acid receptor antagonist (Ki=0.22 μM) . LE-540 is promising for research of cancers (particularly breast and lung cancer) [1].

• UNSPSC :

  12352005

• Target :

  RAR/RXR

• Related Pathways :

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Field of Research :

  Cancer

• Smiles :

  O=C(O)C1=CC=C(C2=NC3=CC4=C(C(C)(C)CCC4(C)C)C=C3N(C)C5=C6C=CC=CC6=CC=C52)C=C1

• Molecular Formula :

  C33H32N2O2

• Molecular Weight :

  488.62

• References & Citations :

  [1]Li Y, et al. Identification of a novel class of retinoic acid receptor beta-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells. J Biol Chem. 1999 May 28;274 (22) :15360-6.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  RXRβ

• CAS Number :

  [188645-44-5]