PF-945863

• Description :

  PF-945863 is an orally active macrolide antibiotic that can be used for the research of multidrug resistant respiratory tract bacterial strains[1][2].

• UNSPSC :

  12352005

• Target :

  Antibiotic

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/pf-945863.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1N(C2CN([C@@H](C3=CC=NC4=C3C=CC=N4)C)C2)[C@@]([C@H]5C)([H])[C@@](C)([C@H](OC([C@@H](C([C@H](C)[C@@H](O[C@@]6([H])[C@@H]([C@H](C[C@@H](C)O6)N(C)C)O)[C@@](OC)(C)C[C@@H](C)C5=O)=O)C)=O)CC)O1

• Molecular Formula :

  C44H65N5O10

• Molecular Weight :

  824.01

• References & Citations :

  [1]Zientek M, et al. In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase. Drug Metab Dispos. 2010;38 (8) :1322-1327.|[2]Magee TV, et al. Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. J Med Chem. 2009;52 (23) :7446-7457.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Macrolide

• CAS Number :

  [893556-85-9]