MK-0674

• Description:

  MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S[1].

• UNSPSC:

  12352005

• Target:

  Cathepsin

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/MK-0674.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC (F) (F) [C@H] (C1=CC=C (C2=CC=C (C=C2) [C@@H] (O) C (F) F) C=C1) N[C@@H] (CC (C) (F) C) C (NC3 (CC3) C#N) =O

• Molecular Formula:

  C26H27F6N3O2

• Molecular Weight:

  527.50

• References & Citations:

  [1]Isabel E, et al. The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor. Bioorg Med Chem Lett. 2010 Feb 1;20 (3) :887-92.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Cathepsin K

• CAS Number:

  887781-62-6