MK-0674

• Description :

  MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S[1].

• UNSPSC :

  12352005

• Target :

  Cathepsin

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/MK-0674.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC(F)(F)[C@H](C1=CC=C(C2=CC=C(C=C2)[C@@H](O)C(F)F)C=C1)N[C@@H](CC(C)(F)C)C(NC3(CC3)C#N)=O

• Molecular Formula :

  C26H27F6N3O2

• Molecular Weight :

  527.50

• References & Citations :

  [1]Isabel E, et al. The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor. Bioorg Med Chem Lett. 2010 Feb 1;20 (3) :887-92.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cathepsin K

• CAS Number :

  [887781-62-6]