CHMFL-BTK-01

CAT: 0804-HY-101521Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-101521Size:1 Each
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AVAILABILITY: InStock
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Description
CHMFL-BTK-01 (compound 9) is a highly selective irreversible BTK inhibitor, with an IC50 of 7 nM. CHMFL-BTK-01 (compound 9) potently inhibited BTK Y223 auto-phosphorylation[1].
CAS Number
[2095280-64-9]
UNSPSC
12352005
Hazard Statement
H302
Target
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/chmfl-btk-01.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC(C(C=C2NC3=CC=C(C(N4CCOCC4)=O)C(NC(C=C)=O)=C3)=CN(C)C2=O)=C1C)C5=CC=C(C(C)(C)C)C=C5
Molecular Formula
C38H41N5O5
Molecular Weight
647.76
Precautions
P264-P270-P330-P501
References & Citations
[1]Liang Q, et al. Discovery of N- (3- (5- ((3-acrylamido-4- (morpholine-4-carbonyl) phenyl) amino) -1-methyl-6-oxo-1,6-dihydropyridin-3-yl) -2-methylphenyl) -4- (tert-butyl) benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor. Eur J Med Chem. 2017 May 5;131:107-125.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
MBS5768897CHMFL-BTK-01
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A12538-25CHMFL-BTK-01 25mg
A12538-1CHMFL-BTK-01 1mg
A12538-5CHMFL-BTK-01 5mg
A12538-100CHMFL-BTK-01 100mg
A12538-50CHMFL-BTK-01 50mg
MBS5766345-01CHMFL-KIT-033
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