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CHMFL-ABL-053

CAT: 0804-HY-101268Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101268Size:1 Each
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Description
CHMFL-ABL-053 (Compound 18a) is a potent, selective, and orally available BCR-ABL, SRC and p38 kinase inhibitor with IC50 values of 70, 90 and 62 nM against ABL1, SRC and p38, respectively[1].
CAS Number
1808287-83-3
UNSPSC
12352005
Target
Bcr-Abl; p38 MAPK; Src
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/chmfl-abl-053.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CN=C(NC2=CC=C(C)C(N)=C2)N=C1NC)NC3=CC(NC(C4=CC=CC(C(F)(F)F)=C4)=O)=CC=C3C
Molecular Formula
C28H26F3N7O2
Molecular Weight
549.55
References & Citations
[1]Liang X, et al. Discovery of 2- ((3-Amino-4-methylphenyl) amino) -N- (2-methyl-5- (3- (trifluoromethyl) benzamido) phenyl) -4- (methylamino) pyrimidine-5-carboxamide (CHMFL-ABL-053) as a Potent, Selective, and Orally Available BCR-ABL/SRC/p38 Kinase Inhibitor for Chronic Myeloid Leukemia. J Med Chem. 2016 Mar 10;59 (5) :1984-2004.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Abl; p38 MAPK

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