CHMFL-ABL-053

• Description:

  CHMFL-ABL-053 (Compound 18a) is a potent, selective, and orally available BCR-ABL, SRC and p38 kinase inhibitor with IC50 values of 70, 90 and 62 nM against ABL1, SRC and p38, respectively[1].

• UNSPSC:

  12352005

• Target:

  Bcr-Abl; p38 MAPK; Src

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/chmfl-abl-053.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CN=C(NC2=CC=C(C)C(N)=C2)N=C1NC)NC3=CC(NC(C4=CC=CC(C(F)(F)F)=C4)=O)=CC=C3C

• Molecular Formula:

  C28H26F3N7O2

• Molecular Weight:

  549.55

• References & Citations:

  [1]Liang X, et al. Discovery of 2- ((3-Amino-4-methylphenyl) amino) -N- (2-methyl-5- (3- (trifluoromethyl) benzamido) phenyl) -4- (methylamino) pyrimidine-5-carboxamide (CHMFL-ABL-053) as a Potent, Selective, and Orally Available BCR-ABL/SRC/p38 Kinase Inhibitor for Chronic Myeloid Leukemia. J Med Chem. 2016 Mar 10;59 (5) :1984-2004.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Abl; p38 MAPK

• CAS Number:

  [1808287-83-3]