LSD1-IN-5

• Description:

  LSD1-IN-5 (Compound 4e) is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 121 nM. LSD1-IN-5 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1[1].

• UNSPSC:

  12352005

• Target:

  Histone Demethylase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/lsd1-in-5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=C(O)C=C(Br)C(/C=C/C2=CC(/C(N)=N/O)=CC=C2)=C1

• Molecular Formula:

  C15H13BrN2O3

• Molecular Weight:

  349.18

• References & Citations:

  [1]Duan YC, et al. Discovery of resveratrol derivatives as novel LSD1 inhibitors: Design, synthesis and their biological evaluation. Eur J Med Chem. 2017 Jan 27;126:246-258.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  KDM1/LSD1

• CAS Number:

  [2035912-55-9]