LSD1-IN-5

• Description :

  LSD1-IN-5 (Compound 4e) is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 121 nM. LSD1-IN-5 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1[1].

• UNSPSC :

  12352005

• Target :

  Histone Demethylase

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/lsd1-in-5.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC1=C(O)C=C(Br)C(/C=C/C2=CC(/C(N)=N/O)=CC=C2)=C1

• Molecular Formula :

  C15H13BrN2O3

• Molecular Weight :

  349.18

• References & Citations :

  [1]Duan YC, et al. Discovery of resveratrol derivatives as novel LSD1 inhibitors: Design, synthesis and their biological evaluation. Eur J Med Chem. 2017 Jan 27;126:246-258.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  KDM1/LSD1

• CAS Number :

  [2035912-55-9]