THK-523

• UNSPSC Description:

  THK-523 has demonstrated its high affinity and selectivity for tau pathology both in vitro and in vivo. 18F-THK523 is a potent tau imaging radiotracer.?18F-THK523 is a potent in vivo tau imaging ligand for Alzheimer's disease[1].

• Target Antigen:

  Amyloid-β

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/thk-523.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=CC=C(C2=NC3=CC=C(OCCF)C=C3C=C2)C=C1

• Molecular Weight:

  282.31

• References & Citations:

  [1]Ryuichi Harada, et al. Comparison of the binding characteristics of [¹⁸F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology. Eur J Nucl Med Mol Imaging. 2013 Jan;40(1):125-32.|[2]Michelle T Fodero-Tavoletti, 18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease. Brain. 2011 Apr;134(Pt 4):1089-100.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1573029-17-0