AGG-523

• Description :

  AGG-523 (PF-5212371) is a reversible, non-hydroxamate, zinc-binding selective aggrecanase 1 (ADAMTS4) and aggrecanase 2 (ADAMTS5) inhibitor. AGG-523 can be used for the study of osteoarthritis (OA) [1].

• Product Name Alternative :

  PF-5212371

• UNSPSC :

  12352005

• Target :

  ADAMTS

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Inflammation/Immunology

• Purity :

  99.3200

• Smiles :

  FC(C=C1)=CC=C1CC(C)(C)NC([C@H](CCC(O)=O)NC(C2=CC=C(C3=CC=CC=C3)C=C2)=O)=O

• Molecular Formula :

  C28H29FN2O4

• Molecular Weight :

  476.54

• References & Citations :

  [1]Wang K, et al. Investigational drugs for the treatment of osteoarthritis. Expert Opin Investig Drugs. 2015;24 (12) :1539-56.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [920289-29-8]