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AGG-523

CAT: 0804-HY-160822-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-160822-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AGG-523 (PF-5212371) is a reversible, non-hydroxamate, zinc-binding selective aggrecanase 1 (ADAMTS4) and aggrecanase 2 (ADAMTS5) inhibitor. AGG-523 can be used for the study of osteoarthritis (OA) [1].
CAS Number
[920289-29-8]
Product Name Alternative
PF-5212371
UNSPSC
12352005
Target
ADAMTS
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Purity
99.3200
Smiles
FC(C=C1)=CC=C1CC(C)(C)NC([C@H](CCC(O)=O)NC(C2=CC=C(C3=CC=CC=C3)C=C2)=O)=O
Molecular Formula
C28H29FN2O4
Molecular Weight
476.54
References & Citations
[1]Wang K, et al. Investigational drugs for the treatment of osteoarthritis. Expert Opin Investig Drugs. 2015;24 (12) :1539-56.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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