THK-5105

CAT: 0804-HY-101181Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-101181Size:1 Each
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Description
THK-5105, an arylquinoline derivative, displays high binding affinity to tau fibrils. THK-5105 has high binding affinity to tau protein aggregates and tau-rich Alzheimer disease (AD) brain homogenates. 18F-THK-5105 has the potential to act as a tau imaging PET probe[1].
CAS Number
[1374107-46-6]
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/thk-5105.html
Solubility
10 mM in DMSO
Smiles
OC(CF)COC1=CC=C2N=C(C3=CC=C(N(C)C)C=C3)C=CC2=C1
Molecular Formula
C20H21FN2O2
Molecular Weight
340.39
References & Citations
[1]Nobuyuki Okamura, et al. Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease. J Nucl Med. 2013 Aug;54 (8) :1420-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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