THK-5105

• Description:

  THK-5105, an arylquinoline derivative, displays high binding affinity to tau fibrils. THK-5105 has high binding affinity to tau protein aggregates and tau-rich Alzheimer disease (AD) brain homogenates. 18F-THK-5105 has the potential to act as a tau imaging PET probe[1].

• UNSPSC:

  12352005

• Target:

  Microtubule/Tubulin

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Cytoskeleton

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/thk-5105.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC(CF)COC1=CC=C2N=C(C3=CC=C(N(C)C)C=C3)C=CC2=C1

• Molecular Formula:

  C20H21FN2O2

• Molecular Weight:

  340.39

• References & Citations:

  [1]Nobuyuki Okamura, et al. Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease. J Nucl Med. 2013 Aug;54 (8) :1420-7.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1374107-46-6]