LXRβ agonist-2
CAT:
804-HY-100469
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
LXRβ agonist-2
- CAS Number: 1949801-52-8
- UNSPSC Description: LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM, displays 28.5-fold selectivity over LXRα (EC50=200 nM) and used in the treatment of atherosclerosis[1].
- Target Antigen: LXR
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
- Applications: Neuroscience-Neuromodulation
- Field of Research: Cardiovascular Disease
- Assay Protocol: https://www.medchemexpress.com/lxr-beta-agonist-2.html
- Solubility: 10 mM in DMSO
- Smiles: OC(C(F)(F)F)(C(F)(F)F)C1=CC(CCC)=C(OC2=CC(O)=C(C(CN3C(N[C@@](C)(C4=NC=C(OC(C)C)C=C4)C3=O)=O)=O)C=C2)C=C1
- Molecular Weight: 683.59
- References & Citations: [1]Koura M,et al. Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency and β-selectivity of liver X receptor agonist. Bioorg Med Chem. 2016 Aug 15;24(16):3436-46.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported