AMG-222

AMG-222

• CAS Number: 913978-37-7
• UNSPSC Description: AMG-222 is a dipeptidyl peptidase IV (DPP-IV) inhibitor that exerts its inhibitory effect by tightly and reversibly binding to DPPIV. AMG 222 binds to human plasma proteins in a saturable and concentration-dependent manner, with a binding rate of 80.8% at 1 nM, while the binding rate decreases to 29.4% at concentrations above 100 nM. AMG-222 can be used in research related to diabetes[1].
• Target Antigen: Dipeptidyl Peptidase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/amg-222.html
• Smiles: O=C(C1=CC=C(C(C2=NNN=N2)(C[C@@H](NCC(N3[C@H](C#N)CCC3)=O)C)C4=CC=C(C(N(C)C)=O)C=C4CC5)C5=C1)N(C)C
• Molecular Weight: 597.71
• References & Citations: [1]Greene R J, et al. Target-mediated metabolism and target-mediated drug disposition of the DPPIV inhibitor AMG 222[J]. Xenobiotica, 2011, 41(11): 945-957.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported