AZ'3137

• Bioactivity:

  AZ'3137 (Compound 22) is an orally active PROTAC-based androgen receptor (AR) degrader, exhibiting a DC50 value of 22 nM. It inhibits cell proliferation in LNCaP cells with a GI50 of 74 nM. Additionally, AZ'3137 suppresses AR signaling and tumor growth in a prostate cancer mouse model.

• Smiles:

  N#CC1=CC=C(C(F)=C1C(F)(F)F)N2CCC(C3=CC=C(C=C3)N4CCC(CN5CCN(C6=CC(OC)=C7C(=O)N(CC7=C6)C8C(=O)NC(=O)CC8)CC5)CC4)CC2

• Molecular Formula:

  C43H47F4N7O4

• Molecular Weight:

  801.87

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2960179-55-7