AZ'3137

CAT: 0931-T89238-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T89238-01Size:10 mg
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CAS Number
2960179-55-7
Bioactivity
AZ'3137 (Compound 22) is an orally active PROTAC-based androgen receptor (AR) degrader, exhibiting a DC50 value of 22 nM. It inhibits cell proliferation in LNCaP cells with a GI50 of 74 nM. Additionally, AZ'3137 suppresses AR signaling and tumor growth in a prostate cancer mouse model.
Smiles
N#CC1=CC=C(C(F)=C1C(F)(F)F)N2CCC(C3=CC=C(C=C3)N4CCC(CN5CCN(C6=CC(OC)=C7C(=O)N(CC7=C6)C8C(=O)NC(=O)CC8)CC5)CC4)CC2
Molecular Formula
C43H47F4N7O4
Molecular Weight
801.87
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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