NHC-diphosphate

NHC-diphosphate

• CAS Number: 39023-73-9
• UNSPSC Description: NHC-diphosphate is an active phosphorylated?intracellular metabolite?of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form[1]. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication?of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV)? and hepatitis C virus?(HCV)[1].
• Target Antigen: Endogenous Metabolite; Enterovirus; HCV; SARS-CoV; Topoisomerase
• Type: Reference compound
• Related Pathways: Anti-infection;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/nhc-diphosphate.html
• Smiles: O[C@H]([C@@H]1O)[C@@](N(C=C/C2=N\O)C(N2)=O)([H])O[C@@H]1CO[P](O[P](O)(O)=O)(O)=O
• Molecular Weight: 419.18
• References & Citations: [1]Brenda I Hernandez-Santiago, et al. Metabolism of the anti-hepatitis C virus nucleoside beta-D-N4-hydroxycytidine in different liver cells. Antimicrob Agents Chemother. 2004 Dec;48(12):4636-42|[2]Maryam Ehteshami, et al. Characterization of β-d- N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.
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