PF-3837

• UNSPSC Description:

  PF-3837 is an Mps1 kinase inhibitor with a Ki value of 0.33 nM and an IC50 value of 5.5 nM. PF-3837 interferes with the cell cycle checkpoint by inhibiting Mps1 catalytic activity, reducing genomic stability, thereby inducing cancer cell apoptosis (Apoptosis). PF-3837 can be used in research on breast cancer[1].

• Target Antigen:

  Apoptosis; Mps1

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pf-3837.html

• Smiles:

  N#CC1=CNC2=NC(NC3=CC=C(N4CCOCC4)N=C3C)=NC(NC(C)(CO)C)=C12

• Molecular Weight:

  422.48

• References & Citations:

  [1]Martinez R, et al. Mitotic checkpoint kinase Mps1 has a role in normal physiology which impacts clinical utility[J]. PloS one, 2015, 10(9): e0138616.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2772910-13-9