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PF-3837

CAT: 0804-HY-164518Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-164518Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-3837 is an Mps1 kinase inhibitor with a Ki value of 0.33 nM and an IC50 value of 5.5 nM. PF-3837 interferes with the cell cycle checkpoint by inhibiting Mps1 catalytic activity, reducing genomic stability, thereby inducing cancer cell apoptosis (Apoptosis) . PF-3837 can be used in research on breast cancer[1].
CAS Number
[2772910-13-9]
UNSPSC
12352005
Target
Apoptosis; Mps1
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pf-3837.html
Smiles
N#CC1=CNC2=NC(NC3=CC=C(N4CCOCC4)N=C3C)=NC(NC(C)(CO)C)=C12
Molecular Formula
C21H26N8O2
Molecular Weight
422.48
References & Citations
[1]Martinez R, et al. Mitotic checkpoint kinase Mps1 has a role in normal physiology which impacts clinical utility[J]. PloS one, 2015, 10 (9) : e0138616.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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