AChE/BuChE-IN-5

AChE/BuChE-IN-5

• UNSPSC Description: AChE/BuChE-IN-5 (compound 5a) is a dual target inhibitor. AChE/BuChE-IN-5 has excellent nanomolar inhibitory activity on acetylcholinesterase (AChE) (IC50=46.9 nM) and butyryl cholinesterase (BuChE) (IC50=3.5 nM). AChE/BuChE-IN-5 can be used for Alzheimer's Disease research[1].
• Target Antigen: Cholinesterase (ChE)
• Type: Reference compound
• Related Pathways: Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/ache-buche-in-5.html
• Solubility: 10 mM in DMSO
• Smiles: C1(NC2=NN=C(O2)C3=CC(C4=CC=CC=C4)=CN=C3)=CC=CC=C1
• Molecular Weight: 314.34
• References & Citations: [1]Zaafar D, et al. Unleashing new MTDL AChE and BuChE inhibitors as potential anti-AD therapeutic agents: In vitro, in vivo and in silico studies[J]. International Journal of Biological Macromolecules, 2024: 131740.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported