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AChE/BuChE-IN-3

CAT: 0804-HY-147939Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147939Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AChE/BuChE-IN-3 is a potent and blood-brain barrier (BBB) penetrant AChE and BuChE dual inhibitor with IC50s of 0.65 μM and 5.77 μM for AChE and BuChE. AChE/BuChE-IN-3 also inhibits Aβ1-42 aggregation. AChE/BuChE-IN-3 has effectively neuroprotective activities and nearly no toxicity on SH-SY5Y cells. AChE/BuChE-IN-3 can be used for researching Alzheimer's disease[1].
CAS Number
2742707-47-5
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ache-buche-in-3.html
Solubility
10 mM in DMSO
Smiles
FC(C1=CC=C(CN2N=NC(COC3=CC(OC)=C4CCC(C5=CC(OC)=C(OC)C(OC)=C5)OC4=C3)=C2)C=C1)(F)F
Molecular Formula
C30H30F3N3O6
Molecular Weight
585.57
References & Citations
[1]Shi S, et al. Semi-synthesis and biological evaluation of flavone hybrids as multifunctional agents for the potential treatment of Alzheimer's disease. Bioorg Chem. 2020 Jul;100:103917.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE

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