AChE-IN-5

• UNSPSC Description:

  AChE-IN-5 (compound 5) exhibits strong in vitro bioactivity against AChE/5-HT1A/SERT and exhibits good BBB permeability. AChE-IN-5 shows IC50 value 2.29 nM against AChE, EC50 value 58.6 nM against 5-HT1A and IC50 value against SERT. Orally active[1].

• Target Antigen:

  5-HT Receptor; Cholinesterase (ChE); Serotonin Transporter

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ache-in-5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N#CC1=CC2=C(NC=C2CCCCN3CCN(CC3)C4=CC=C(C=C4)C(CCC5CCN(CC5)CC6=CC=CC=C6)=O)C=C1

• Molecular Weight:

  587.80

• References & Citations:

  [1]Li X, et al. The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression. Eur J Med Chem. 2022;229:114045.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported