AChE-IN-5

• Description :

  AChE-IN-5 (compound 5) exhibits strong in vitro bioactivity against AChE/5-HT1A/SERT and exhibits good BBB permeability. AChE-IN-5 shows IC50 value 2.29 nM against AChE, EC50 value 58.6 nM against 5-HT1A and IC50 value against SERT. Orally active[1].

• UNSPSC :

  12352005

• Target :

  5-HT Receptor; Cholinesterase (ChE) ; Serotonin Transporter

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ache-in-5.html

• Solubility :

  10 mM in DMSO

• Smiles :

  N#CC1=CC2=C(NC=C2CCCCN3CCN(CC3)C4=CC=C(C=C4)C(CCC5CCN(CC5)CC6=CC=CC=C6)=O)C=C1

• Molecular Formula :

  C38H45N5O

• Molecular Weight :

  587.80

• References & Citations :

  [1]Li X, et al. The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression. Eur J Med Chem. 2022;229:114045.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT1 Receptor; AChE