PSMA-azide

• Description :

  PSMA-azide is a prostate-specific membrane antigen (PSMA) ligand. PSMA-azide inhibits PSMA-dependent NAAG (N-acetylaspartylglutamic acid) hydrolysis, with an IC50 of 9 nM and a Ki of 1 nM. PSMA-azide contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups[1].

• CAS Number :

  [2374814-84-1]

• UNSPSC :

  12352203

• Target :

  PSMA

• Type :

  ADC Related

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/psma-val-cit-pab-azide.html

• Purity :

  99.43

• Solubility :

  DMSO : 200 mg/mL (ultrasonic)

• Smiles :

  O=C(N[C@H](C(NCCCN=[N+]=[N-])=O)CC(C=C1)=CC=C1O)[C@@H](NC(CCC(NCCCCCC(N(CCCC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)CC2=CC(Cl)=CC=C2)=O)=O)=O)CC3=CC=CC=C3

• Molecular Formula :

  C50H65ClN10O13

• Molecular Weight :

  1049.56

• References & Citations :

  [1]Machulkin AE, et al. Synthesis and Biological Evaluation of PSMA Ligands with Aromatic Residues and Fluorescent Conjugates Based on Them. J Med Chem. 2021 Apr 22;64 (8) :4532-4552.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported