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PSMA-D5

CAT: 0804-HY-P10781-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P10781-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PSMA-D5 has a binding affinity for PSMA with Ki of 0.21 nM and can be used for PSMA tracing after radiolabeling. PSMA-D5 ([68Ga]-labeled) contains a DOTA chelator, allowing convenient labeling with therapeutic radionuclides such as 177Lu and 225Ac. PSMA-D5 ([68Ga]-labeled) shows excellent pharmacokinetic properties, exhibiting remarkable tumor uptake in 22Rv1 tumors[1]. PSMA-D5 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs) .
CAS Number
[3056440-83-3]
UNSPSC
12352209
Target
PSMA; Radionuclide-Drug Conjugates (RDCs)
Related Pathways
Antibody-drug Conjugate/ADC Related; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.61
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC([C@@H](NC(N[C@H](C(O)=O)CCC(O)=O)=O)CCCCNC(C1=CC(C2=CC=C(C=C2)NC(CCNC(CN3CCN(CCN(CCN(CC3)CC(O)=O)CC(O)=O)CC(O)=O)=O)=O)=CC(C(NCCCC[C@H](NC(N[C@@H](CCC(O)=O)C(O)=O)=O)C(O)=O)=O)=C1)=O)=O
Molecular Formula
C57H80N12O24
Molecular Weight
1317.31
References & Citations
[1]Chen Y, et al. Synthesis, Preclinical Evaluation, and First-in-Human PET Study of [68Ga]-Labeled Biphenyl-Containing PSMA Tracers. J Med Chem. 2023 Sep 28;66 (18) :13332-13345.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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