MMP-8 Recombinant Rabbit Monoclonal Antibody [JE59-38]

MMP-8 Recombinant Rabbit Monoclonal Antibody [JE59-38]

• Description: Neutrophil collagenase, also known as matrix metalloproteinase-8 (MMP-8) or PMNL collagenase (MNL-CL), is a collagen cleaving enzyme which is present in the connective tissue of most mammals. In humans, the MMP-8 protein is encoded by the MMP8 gene. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The primary function of MMP-8 is the degradation of type I, II and III collagens. In cancer, loss of MMP-8 in the murine MMTV-PyMT breast cancer model has been associated with increased tumor growth and metastatic burden, as well as enhanced tumor vascularity and altered immune cell infiltration. Furthermore, analysis of MMP-8 in breast cancer cell lines revealed a causal connection between MMP-8 activity and IL6 and IL8 production, suggesting a role for MMP-8 in the regulation of the innate immune system.
• Product Name Alternative: CLG 1 antibody CLG1 antibody Collagenase 1 antibody Collagenase 1 neutrophil antibody HNC antibody Matrix metallopeptidase 8 (neutrophil collagenase) antibody Matrix metalloprotease 8 antibody Matrix metalloproteinase-8 antibody MMP 8 antibody MMP-8 antibody Mmp8 antibody MMP8_HUMAN antibody Neutrophil collagenase antibody PMNL CL antibody PMNL collagenase antibody PMNL-CL antibody PMNLCL antibody
• Abbreviation: MMP8, CLG1
• CAS Number: 9000-83-3
• Swiss Prot: P22894 Human, O70138 Mouse, O88766 Rat
• Cellular Locus: Cytoplasmic granule, Secreted, extracellular space, extracellular matrix.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within Human MMP8 aa 101-200 / 467.
• Isotype: IgG
• Clone: JE59-38
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: IHC-P
• Positive Control: Human colon carcinoma tissue, human tonsil tissue, mouse thymus tissue, rat thymus tissue.
• Concentration: 1 mg/mL
• Dilution: IHC-P: 1:200-1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 53 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes