(E/Z) -HA155

• Description:

  (E/Z) -HA155 is a potent autotaxin (ATX) type I inhibitor. (E/Z) -HA155 can be used for researching cancer, fibrotic diseases, inflammation, pain and angiogenesis[1].

• Product Name Alternative:

  KPT-8602

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319

• Target:

  Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/e-z-ha155.html

• Concentration:

  10mM

• Purity:

  99.58

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  OB(O)C1=CC=C(C=C1)COC2=CC=C(C=C2)/C=C(C3=O)\SC(N3CC4=CC=C(C=C4)F)=O

• Molecular Formula:

  C24H19BFNO5S

• Molecular Weight:

  463.29

• Precautions:

  P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

• References & Citations:

  [1]Joncour A, et al. Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors [published correction appears in J Med Chem. 2018 May 10;61 (9) :4270]. J Med Chem. 2017;60 (17) :7371-7392.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Autotaxin

• CAS Number:

  [1229652-22-5]