HA155

• Description:

  HA-155 is a potent and selective autotaxin (ATX) inhibitor with an IC50 of 5.7 nM[1][2][3].

• Product Name Alternative:

  KPT-8602, KPT-8602 (Z-isomer)

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ha155.html

• Purity:

  98.00

• Solubility:

  DMSO : 10 mg/mL (ultrasonic; warming)

• Smiles:

  O=C1N(CC2=CC=C(F)C=C2)C(S/C1=C\C3=CC=C(OCC4=CC=C(B(O)O)C=C4)C=C3)=O

• Molecular Formula:

  C24H19BFNO5S

• Molecular Weight:

  463.29

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Albers HM, et al. Chemical Evolution of Autotaxin Inhibitors. Chem Rev. 2012 May 9;112 (5) :2593-603.|[2]Albers HM, et al. Structure-based design of novel boronic acid-based inhibitors of autotaxin. J Med Chem. 2011 Jul 14;54 (13) :4619-26.|[3]Fulkerson Z, et al. Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells. J Biol Chem. 2011 Oct 7;286 (40) :34654-63.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Autotaxin

• CAS Number:

  [1312201-00-5]