GNE-781

CAT: 0804-HY-108696-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-108696-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
GNE-781 is an orally active, highly potent and selective CBP inhibitor with an IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4 (1) with IC50s of 6.2 nM and 5100 nM, respectively. GNE-781 displays antitumor activity in an MOLM-16 AML xenograft model[1].
CAS Number
[1936422-33-1]
UNSPSC
12352005
Target
Epigenetic Reader Domain; Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GNE-781.html
Purity
98.16
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N1CCC(N(C2CCOCC2)N=C3N4CCCC5=C4C=C(C(F)F)C(C6=CN(C)N=C6)=C5)=C3C1)NC
Molecular Formula
C27H33F2N7O2
Molecular Weight
525.59
References & Citations
[1]Romero FA, et al. GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) . J Med Chem. 2017 Nov 22;60 (22) :9162-9183.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300

Related Products

CatalogName
HY-15351UC-781
HY-W999601CRBN ligand-781
HY-171185CP-611,781
HY-175448GNE-1567
HY-15883-01GNE-900
HY-18163-01GNE-7915
HY-149026-01GNE-064
HY-15766-01GNE-617
HY-150289-01GNE-235
HY-107986-01GNE-6776

Alternative Products

CatalogName
TRC-D447825-2.5MGGNE-781
A19798-5GNE-781 5mg
451392-01GNE-781 discontinued
A19798-50GNE-781 50mg
A19798-1GNE-781 1mg
A19798-10GNE-781 10mg
A19798-25GNE-781 25mg
A19798-100GNE-781 100mg
TRC-B702144-250MGN-Boc Desmethylaminoformyl GNE-781
A19798-10mM-DGNE-781 10mM * 1mL in DMSO

Popular Products