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OATD-02 (hydrochloride)

CAT: 0804-HY-155108B-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-155108B-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OATD-02 hydrochloride is the hydrochloride salt form of OATD-02. OATD-02 hydrochloride an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase1 and Arginase2. OATD-02 hydrochloride is a slow offset inhibitor, blocking intracellular arginases with IC50s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 hydrochloride bolishes tumor immunosuppression induced by both arginases. OATD-02 hydrochloride can be used for melanoma study[1].
UNSPSC
12352211
Target
Arginase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/oatd-02-hydrochloride.html
Purity
99.88
Solubility
H2O : 250 mg/mL (ultrasonic)
Smiles
N[C@]1(C(O)=O)C[C@H](CCB(O)O)CC[C@H]1CN(C)C.[H]Cl
Molecular Formula
C12H26BClN2O4
Molecular Weight
308.61
References & Citations
[1]Borek B, et al. Arginase 1/2 Inhibitor OATD-02: From Discovery to First-in-man Setup in Cancer Immunotherapy. Mol Cancer Ther. 2023;22 (7) :807-817.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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