OATD-02

CAT: 0804-HY-155108Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-155108Size:1 Each
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Description
OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase1 and 2. OATD-02 is a slow offset inhibitor, blocking intracellular arginases with IC50s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 abolishes tumor immunosuppression induced by both arginases. OATD-02 can be used for melanoma study[1].
CAS Number
[2146132-73-0]
UNSPSC
12352211
Target
Arginase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/oatd-02.html
Solubility
10 mM in DMSO
Smiles
N[C@]1(C(O)=O)C[C@H](CCB(O)O)CC[C@H]1CN(C)C
Molecular Formula
C12H25BN2O4
Molecular Weight
272.15
References & Citations
[1]Borek B, et al. Arginase 1/2 Inhibitor OATD-02: From Discovery to First-in-man Setup in Cancer Immunotherapy. Mol Cancer Ther. 2023;22 (7) :807-817.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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