IITZ-02

• Description :

  IITZ-02 is a lysosomotropic Autophagy inhibitor. IITZ-02 enhances autophagosome accumulation but inhibits autophagosomal degradation by impairing lysosomal function, finally inducing the inhibition of autophagy. IITZ-02 abolishes mitochondrial membrane potential and induces apoptosis through the mitochondria-mediated pathway. IITZ-02 has a potent antitumor activity in MDA-MB-231 xenograft mouse models. IITZ-02 can be used for cancers research[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Autophagy; Mitochondrial Metabolism

• Related Pathways :

  Apoptosis; Autophagy; Metabolic Enzyme/Protease

• Field of Research :

  Cancer

• Purity :

  96.51

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  COC(C=C1)=CC=C1NC2=NC(N3CCOCC3)=NC(NC4=CC=C(C5=NC6=C(N5)C=CC=C6)C=C4)=N2

• Molecular Formula :

  C27H26N8O2

• Molecular Weight :

  494.55

• References & Citations :

  [1]Guntuku L, et al. IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo. Oncogene. 2019 Jan;38 (4) :581-595.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1807988-46-0]