IITZ-02

CAT: 0804-HY-203817-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-203817-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IITZ-02 is a lysosomotropic Autophagy inhibitor. IITZ-02 enhances autophagosome accumulation but inhibits autophagosomal degradation by impairing lysosomal function, finally inducing the inhibition of autophagy. IITZ-02 abolishes mitochondrial membrane potential and induces apoptosis through the mitochondria-mediated pathway. IITZ-02 has a potent antitumor activity in MDA-MB-231 xenograft mouse models. IITZ-02 can be used for cancers research[1].
CAS Number
[1807988-46-0]
UNSPSC
12352005
Target
Apoptosis; Autophagy; Mitochondrial Metabolism
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease
Field of Research
Cancer
Purity
96.51
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC(C=C1)=CC=C1NC2=NC(N3CCOCC3)=NC(NC4=CC=C(C5=NC6=C(N5)C=CC=C6)C=C4)=N2
Molecular Formula
C27H26N8O2
Molecular Weight
494.55
References & Citations
[1]Guntuku L, et al. IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo. Oncogene. 2019 Jan;38 (4) :581-595.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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