IITZ-02

• Description:

  IITZ-02 is a lysosomotropic Autophagy inhibitor. IITZ-02 enhances autophagosome accumulation but inhibits autophagosomal degradation by impairing lysosomal function, finally inducing the inhibition of autophagy. IITZ-02 abolishes mitochondrial membrane potential and induces apoptosis through the mitochondria-mediated pathway. IITZ-02 has a potent antitumor activity in MDA-MB-231 xenograft mouse models. IITZ-02 can be used for cancers research[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Autophagy; Mitochondrial Metabolism

• Related Pathways:

  Apoptosis; Autophagy; Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Purity:

  96.51

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  COC(C=C1)=CC=C1NC2=NC(N3CCOCC3)=NC(NC4=CC=C(C5=NC6=C(N5)C=CC=C6)C=C4)=N2

• Molecular Formula:

  C27H26N8O2

• Molecular Weight:

  494.55

• References & Citations:

  [1]Guntuku L, et al. IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo. Oncogene. 2019 Jan;38 (4) :581-595.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1807988-46-0]