LXJ-02

• Description :

  LXJ-02 is a potent inhibitor of EDPs/EBP peptide–protein interaction, with the KD of 117 μM for EDPs. LXJ-02 activates the macrophage-MMP-12 axis to increase MMP-12 expression and degrade ECM components like elastin[1].

• UNSPSC :

  12352209

• Target :

  MMP

• Type :

  Peptides

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/lxj-02.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N1[C@H](C(N[C@H](C(N)=O)C)=O)CCC1)CO)=O)C)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCC(N)=O)=O)C)=O)CO)(=O)[C@H]2N(C([C@@H](NC(CNC([C@@](NC([C@@H](NC(CCOCCOCCNC(CCOCCOCCNC(CC[C@H](NC(CCCCCCCCCCCCCCCCCCC(O)=O)=O)C(O)=O)=O)=O)=O)[C@H](C)C)=O)(CC)C)=O)=O)CO)=O)CCC2

• Molecular Formula :

  C94H159N19O34

• Molecular Weight :

  2099.37

• References & Citations :

  [1]Yixiang Wang, et al. Design and Synthesis of Novel Ultralong-Acting Peptides as EDP-EBP Interaction Inhibitors for Pulmonary Fibrosis Treatment. J Med Chem. 2024 Apr 25;67 (8) :6624-6637.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [2672508-37-9]