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CDK2/4-IN-1

CAT: 0804-HY-159155Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-159155Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK2/4-IN-1 (compound B-4a) is a CDK2/4 inhibitor and a tubulin polymerization inhibitor. CDK2/4-IN-1 can be used in cancer research[1].
UNSPSC
12352005
Target
CDK; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk2-4-in-1.html
Smiles
O=C1C(OC)=C[C@@H]2C(C=C3)=C([C@H]1C4=C2C5=C(C=C(OC)C(OC)=C5OC)CC[C@@H]4NC(C)=O)C=C3C6=CC=C(OS(=O)(C(F)(F)F)=O)C([Si](C)(C)C)=C6
Molecular Formula
C38H40F3NO9SSi
Molecular Weight
771.87
References & Citations
[1]Iqbal Lone W, et al. Discovery of colchicine aryne cycloadduct as a potent molecule for the abrogation of epithelial to mesenchymal transition via modulating cell cycle regulatory CDK-2 and CDK-4 kinases in breast cancer cells. Bioorg Chem. 2024 Sep;150:107581.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; CDK4

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