CDK2/9-IN-1

• Description:

  CDK2/9-IN-1 (compound 20a) is an orally active dual inhibitor of CDK2 and CDK9 with IC50 values are 0.004 μM and 0.009 μM respectively. CDK2/9-IN-1 induces apoptosis by regulating G2/M cell cycle arrest. CDK2/9-IN-1 has antitumor activity[1].

• UNSPSC:

  12352211

• Target:

  Apoptosis; CDK

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Smiles:

  O=S(C1=CC=C(NC2=NC(NC3=NC=CS3)=C(C=N2)C)C=C1)(N)=O

• Molecular Formula:

  C14H14N6O2S2

• Molecular Weight:

  362.43

• References & Citations:

  [1]Zhang B, et al. Structure-Guided Discovery of Novel N4- (Substituted Thiazol-2-yl) -N2- (4-Substituted phenyl) pyrimidine-2,4-Diamines as Potent CDK2 and CDK9 Dual Inhibitors with High Oral Bioavailability. J Med Chem. 2025 Jan 8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CDK2; CDK9

• CAS Number:

  2222285-23-4