CYC-116

• Description :

  CYC-116 is a potent aurora A and aurora B inhibitor with Kis of 8 and 9 nM, respectively.

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H320

• Target :

  Aurora Kinase

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/CYC-116.html

• Purity :

  99.05

• Solubility :

  DMSO : 15 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles :

  CC1=C(SC(N)=N1)C2=NC(NC3=CC=C(C=C3)N4CCOCC4)=NC=C2

• Molecular Formula :

  C18H20N6OS

• Molecular Weight :

  368.46

• Precautions :

  H315, H319, H320

• References & Citations :

  [1]Wang S, et al. Discovery of N-phenyl-4- (thiazol-5-yl) pyrimidin-2-amine aurora kinase inhibitors. J Med Chem. 2010 Jun 10;53 (11) :4367-78.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  Aurora A; Aurora B

• CAS Number :

  [693228-63-6]