CYC-116

• Description:

  CYC-116 is a potent aurora A and aurora B inhibitor with Kis of 8 and 9 nM, respectively.

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H320

• Target:

  Aurora Kinase

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/CYC-116.html

• Purity:

  99.05

• Solubility:

  DMSO : 15 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles:

  CC1=C (SC (N) =N1) C2=NC (NC3=CC=C (C=C3) N4CCOCC4) =NC=C2

• Molecular Formula:

  C18H20N6OS

• Molecular Weight:

  368.46

• Precautions:

  H315, H319, H320

• References & Citations:

  [1]Wang S, et al. Discovery of N-phenyl-4- (thiazol-5-yl) pyrimidin-2-amine aurora kinase inhibitors. J Med Chem. 2010 Jun 10;53 (11) :4367-78.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  Aurora A; Aurora B

• CAS Number:

  693228-63-6