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EGFR-IN-116

CAT: 0804-HY-163723Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163723Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR-IN-116 (compound 14D) is an anticancer agent. EGFR-IN-116 against EGFR has the IC50 values​of EGFR, VEGFR-2 and Topo II are 0.103 μM, 0.069 μM and 19.74 μM, respectively[1].
UNSPSC
12352005
Target
EGFR; Topoisomerase; VEGFR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-116.html
Smiles
O=C(NC1=CC=C(C)C=C1)CN2N=NC(CSC(N3C4=CC=CC=C4)=NC5=C(C=CC=C5)C3=O)=C2
Molecular Formula
C26H22N6O2S
Molecular Weight
482.56
References & Citations
[1]El Hamaky NFM, et al. Novel quinazolin-2-yl 1,2,3-triazole hybrids as promising multi-target anticancer agents: Design, synthesis, and molecular docking study. Bioorg Chem. 2024 Jul;148:107437.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; Topo II; VEGFR2/KDR/Flk-1

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