HEAL-116

• Description:

  HEAL-116 is a potent, specific and orally active 3β-hydroxysteroid dehydrogenase type 1 (3βHSD1) inhibitor with an IC50 of 1.18 μM and a KD of 1.32 μM. HEAL-116 inhibits DHEA (HY-14650) metabolism and DHEA-induced target gene expression and cell proliferation. HEAL-116 can be used for cancer research, such as prostate cancer[1].

• UNSPSC:

  12352100

• Target:

  3β-HSD

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Smiles:

  OC1=CC (OC=C (C2=CC=C (Cl) C (CN3CCOCC3) =C2) C4=O) =C4C=C1

• Molecular Formula:

  C20H18ClNO4

• Molecular Weight:

  371.81

• References & Citations:

  [1]He D, et al. Fine structural design of 3βHSD1 inhibitors for prostate cancer therapy. Proc Natl Acad Sci U S A. 2025 Jul;122 (26) :e2422267122.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  3β-HSD I

• CAS Number:

  3059767-85-7