VK4-116

• Description:

  VK4-116 (Compound 19) is a selective Dopamine D3 receptor (D3R) antagonist with a Ki of 6.84 nM.VK4-116 significantly inhibits Oxycodone-induced hyperlocomotion and locomotor sensitization in mouse models. VK4-116 with pretreatment also inhibits the acquisition of Oxycodone-induced conditioned place preference (CPP) in rat models[1].

• UNSPSC:

  12352005

• Target:

  Dopamine Receptor

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Field of Research:

  Neurological Disease

• Smiles:

  O=C(C1=CC2=C(N1)C=CC=C2)NCCC(CN3CCN(CC3)C4=CC(CC)=CC(Cl)=C4OC)O

• Molecular Formula:

  C26H33ClN4O3

• Molecular Weight:

  485.02

• References & Citations:

  [1]Kumar V, et al. Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment. J Med Chem. 2016 Aug 25;59 (16) :7634-50.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  D3 Receptor

• CAS Number:

  [1982347-43-2]