116-9e

CAT: 0804-HY-116683-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-116683-01Size:5 mg
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Description
116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis. 116-9e inhibits tumor antigen (TAg) ’s endogenous ATPase activity and the TAg-mediated activation of Hsp70[1][2].
CAS Number
[831217-43-7]
Product Name Alternative
MAL2-11B
UNSPSC
12352005
Hazard Statement
H301, H410
Target
DNA/RNA Synthesis; HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/116-9e.html
Purity
98.28
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CCCCCN1C(C)=C(C(NC1=O)C2=CC=C(C=C2)C3=CC=CC=C3)C(OCC4=CC=CC=C4)=O)O
Molecular Formula
C31H32N2O5
Molecular Weight
512.60
Precautions
H301, H410
References & Citations
[1]Christine M Wright, et al. Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. Virus Res. 2009 Apr;141 (1) :71-80.|[2]Nitika, et al. Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance. Sci Rep. 2020 Aug 14;10 (1) :13831.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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