116-9e

• Description :

  116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis. 116-9e inhibits tumor antigen (TAg) ’s endogenous ATPase activity and the TAg-mediated activation of Hsp70[1][2].

• Product Name Alternative :

  MAL2-11B

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H410

• Target :

  DNA/RNA Synthesis; HSP

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/116-9e.html

• Purity :

  98.28

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(CCCCCN1C(C)=C(C(NC1=O)C2=CC=C(C=C2)C3=CC=CC=C3)C(OCC4=CC=CC=C4)=O)O

• Molecular Formula :

  C31H32N2O5

• Molecular Weight :

  512.60

• Precautions :

  H301, H410

• References & Citations :

  [1]Christine M Wright, et al. Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. Virus Res. 2009 Apr;141 (1) :71-80.|[2]Nitika, et al. Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance. Sci Rep. 2020 Aug 14;10 (1) :13831.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [831217-43-7]