SR 16832

• Description :

  SR 16832 is a dual site covalent PPARγ inhibitor that acts at orthosteric and allosteric sites[1].

• CAS Number :

  [2088135-12-8]

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319

• Target :

  PPAR

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/sr-16832.html

• Purity :

  99.89

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  O=C(NC1=CC=NC2=CC=C(OC)C=C12)C3=CC([N+]([O-])=O)=CC=C3Cl

• Molecular Formula :

  C17H12ClN3O4

• Molecular Weight :

  357.75

• Precautions :

  P264-P280-P302+P352-P305+P351+P338-P362+P364

• References & Citations :

  [1]Brust R, et al. Modification of the Orthosteric PPARγ Covalent Antagonist Scaffold Yields an Improved Dual-Site Allosteric Inhibitor. ACS Chem Biol. 2017 Apr 21;12 (4) :969-978.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PPARγ