PROTAC AR-V7 degrader-1
CAT:
804-HY-145479-04
Size:
25 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PROTAC AR-V7 degrader-1
- CAS Number: 2767440-24-2
- UNSPSC Description: PROTAC AR-V7 degrader-1 (Compound 6) is a potent, orally bioavailable and selective AR-V7 degrader with the DC50 of 0.32 µM by recruiting VHL E3 ligase to Androgen receptor (AR) DNA binding domain (DBD) binder. PROTAC AR-V7 degrader-1 exhibits activity against 22Rv1 cell-line expressing AR-V7 with the EC50 of 0.88 µM[1].
- Target Antigen: Androgen Receptor; PROTACs
- Type: Reference compound
- Related Pathways: PROTAC;Vitamin D Related/Nuclear Receptor
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/protac-ar-v7-degrader-1.html
- Solubility: DMSO : 110 mg/mL (ultrasonic)
- Smiles: O=C(CCCCOC1=CC=C(C2=CSC(N3CCOCC3)=N2)C=C1)N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(N[C@H](C5=CC=C(C=C5)C6=C(N=CS6)C)C)=O)=O
- Molecular Weight: 789.02
- References & Citations: [1]Archana Bhumireddy, et al. Design, synthesis, and biological evaluation of phenyl thiazole-based AR-V7 degraders. Bioorg Med Chem Lett. 2022 Jan 1;55:128448.
- Shipping Conditions: Blue Ice
- Clinical Information: No Development Reported