Aβ aggregation modulator-1

• Description :

  Aβ aggregation modulator-1 is a stimulator of amyloid-β (Aβ) fibrillogenesis. Aβ aggregation modulator-1 binds hydrophobic residues in Aβ peptides and stabilizes β-sheet-rich protofibrils and fibrils. Aβ aggregation modulator-1 accelerates Aβ polymerization and reduces concentrations of small, toxic Aβ oligomers in heterogeneous aggregation reactions. Aβ aggregation modulator-1 suppresses long-term potentiation (LTP) inhibition by Aβ oligomers in hippocampal brain slices. Aβ aggregation modulator-1 can be used for the study of Alzheimer's disease (AD) [1].

• UNSPSC :

  12352005

• Target :

  Amyloid-β; Drug Derivative

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling; Others

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/aβ42-in-6.html

• Smiles :

  O=C1C=C2OC3=CC(O)=C(C4=C(O)C=C(O)C=C4)C=C3N=C2C=C1C5=C(O)C=C(O)C=C5

• Molecular Formula :

  C24H15NO7

• Molecular Weight :

  429.38

• References & Citations :

  [1]Bieschke J, et al. Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils. Nat Chem Biol. 2011 Nov 20;8 (1) :93-101.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [71939-12-3]