PROTAC ACC degrader-1

PROTAC ACC degrader-1

• UNSPSC Description: PROTAC ACC degrader-1 (Compound 9b) is a Acetyl-CoA Carboxylase degrader. PROTAC ACC degrader-1 exhibits superior potency against Aphis craccivora (IC50 = 107.8 μg/mL). (Structure Note: Pink, Target protein ligand (HY-169009); Blue, E3 ligand (HY-10984); Black, linker (HY-W007559)[1].
• Target Antigen: Acetyl-CoA Carboxylase; PROTACs
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;PROTAC
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/protac-acc-degrader-1.html
• Smiles: CC1=C(C2=C(OCCCCCC(NC3=C(C(N(C4C(NC(CC4)=O)=O)C5=O)=O)C5=CC=C3)=O)C6(CCC(OC)CC6)NC2=O)C=C(C)C=C1
• Molecular Weight: 670.75
• References & Citations: [1]Xu Q, et al. Acetyl-CoA Carboxylase Proteolysis-Targeting Chimeras: Conceptual Design and Application as Insecticides. J Agric Food Chem. 2024 Aug 28;72(34):18809-18815.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported