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Ibuprofen-d3 (sodium)

CAT: 0804-HY-78131CS-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-78131CS-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ibuprofen-d3 ((±) -Ibuprofen-d3) sodium is the deuterium labeled Ibuprofen sodium. Ibuprofen sodium is an orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers[1][2][3][4].
CAS Number
1219805-09-0
Product Name Alternative
(±) -Ibuprofen-d3 (sodium)
UNSPSC
12352005
Target
Apoptosis; COX; Isotope-Labeled Compounds; Parasite
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; Others
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease
Purity
99.0
Solubility
10 mM in DMSO|DMF : ≥ 30mg/mL|DMSO : ≥ 50mg/mL|Ethanol : ≥ 50mg/mL
Smiles
O=C(O[Na])C(C([2H])([2H])[2H])C1=CC=C(CC(C)C)C=C1
Molecular Formula
C13H14D3NaO2
Molecular Weight
231.28
References & Citations
[1]Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61 (1) :2-7. |[2]Hassan Akrami, et al. Inhibitory effect of ibuprofen on tumor survival and angiogenesis in gastric cancer cell. Tumour Biol. 2015 May;36 (5) :3237-43. |[3]Nathan D Pennock, et al. Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer. J Immunother Cancer. 2018 Oct 1;6 (1) :98. |[4]M W Konstan, et al. Ibuprofen attenuates the inflammatory response to Pseudomonas aeruginosa in a rat model of chronic pulmonary infection. Implications for antiinflammatory therapy in cystic fibrosis. Am Rev Respir Dis. 1990 Jan;141 (1) :186-92.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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