Hydroxy-α-sanshool

CAT: 0804-HY-N6825-03Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-N6825-03Size:10 mg

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Description

Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC50s of 69 and 1.1 μM, respectively. Hydroxy-α-sanshool can be used for pain research[1][2].

CAS Number

83883-10-7

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; TRP Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hydroxy-alpha-sanshool.html

Concentration

10mM

Purity

99.57

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C/C=C/C=C/C=C\CC/C=C/C(NCC(C)(O)C)=O

Molecular Formula

C16H25NO2

Molecular Weight

263.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Koo JY, et al. Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. Br J Pharmacol. 2009 Aug;157 (8) :1398-409.|[2]Koo JY, et al. Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons. Eur J Neurosci. 2007 Sep;26 (5) :1139-47.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Chemical Information

Hydroxy-Alpha-Sanshool

Hydroxy-alpha-sanshool is a fatty amide.

CAS Number	83883-10-7
PubChem CID	10084135
IUPAC Name	(2E,6Z,8E,10E)-N-(2-hydroxy-2-methylpropyl)dodeca-2,6,8,10-tetraenamide
Molecular Formula	C16H25NO2
Molecular Weight	263.37
XLogP	2.8
Topological Polar Surface Area	49.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	8
Heavy Atom Count	19
Formal Charge	0
Complexity	363

SMILES

C/C=C/C=C/C=C\CC/C=C/C(=O)NCC(C)(C)O

InChI

InChI=1S/C16H25NO2/c1-4-5-6-7-8-9-10-11-12-13-15(18)17-14-16(2,3)19/h4-9,12-13,19H,10-11,14H2,1-3H3,(H,17,18)/b5-4+,7-6+,9-8-,13-12+

InChIKey

LHFKHAVGGJJQFF-UEOYEZOQSA-N

Chemical Structure

2D Structure

CAS: 83883-10-7

CID: 10084135

Formula: C16H25NO2

MW: 263.37

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	263.37
XLogP3	2.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	8
Exact Mass	263.188529040
Monoisotopic Mass	263.188529040
Topological Polar Surface Area	49.3 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	363
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	4
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
AB2245	Hydroxy-ε-sanshool
AB2244	Hydroxy-γ-sanshool
AB2243	Hydroxy-β-sanshool
BUP04863-01	Hydroxy-a-sanshool
T8307-01	Hydroxy-α-sanshool
M21545-01	Hydroxy-α-sanshool
BUP20130-01	Hydroxy-ß-sanshool
TBW01491	alpha-Hydroxy-Sanshool
MBS5759839	Hydroxy-beta-sanshool
MBS5768077	Hydroxy-Epsilon-Sanshool

Hydroxy-α-sanshool

Chemical Information

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