Hydroxy-α-sanshool

• UNSPSC Description:

  Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC50s of 69 and 1.1 μM, respectively. Hydroxy-α-sanshool can be used for pain research[1][2].

• Target Antigen:

  Endogenous Metabolite; TRP Channel

• Type:

  Natural Products

• Related Pathways:

  Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/hydroxy-alpha-sanshool.html

• Purity:

  99.57

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  C/C=C/C=C/C=C\CC/C=C/C(NCC(C)(O)C)=O

• Molecular Weight:

  263.38

• References & Citations:

  [1]Koo JY, et al. Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. Br J Pharmacol. 2009 Aug;157(8):1398-409.|[2]Koo JY, et al. Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons. Eur J Neurosci. 2007 Sep;26(5):1139-47.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  83883-10-7